Combined single-molecule force and fluorescence measurements for biology.

10.1186/1475-4924-2-4

Recent advances in single-molecule techniques allow the application of force to an individual biomolecule whilst simultaneously monitoring its response using fluorescent probes. The effects of applied mechanical load on single-enzyme turnovers, biomolecular interactions and conformational changes can now be studied with nanometer precision and millisecond time resolution.

Combined single-molecule force and fluorescence measurements for biology. - April 14, 2003 - Mark Wallace