Ion Transport and Membrane Channel Formation Using a Peptidomimetic in Droplet Interface Bilayers

10.1039/D4CC05926C

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Peptidomimetic channels. Herein, we present a synthetic peptidomimetic, TBP2, which forms artificial membrane channels within Droplet Interface Bilayers (DIBs). Through real-time electrophysiology, TIRF microscopy, and single-channel recordings, we demonstrate the ability of TBP2 to mediate high-conductance transport of Na⁺ and K⁺ across the DIBs, highlighting its potential for nanobiotechnology applications in cell-free systems.